CAPSAICIN+™ Leave-In Serum is designed to stimulate hairfollicles through its growth phase with an intensive concentration of 5% CAPIXYL™ Peptide Complex combined with a 2% DEFENSCALP™ Solution. Hair loss sufferersmost of the time have the hair growth cycle disrupted by the loss of connectivetissue integrity surrounding the hair follicle, an increase in the inflammatoryprocess in the scalp and is submitted to higher oxidative stress. With aging the decrease number of hair follicle and size offollicle in the scalp will also lead to thinner hair shaft and an increase inhair loss. Chronic inflammation of the hair follicle is considered a contributingfactor.
Defenscalp™ is extracted from rosebay (or fireweed) a common plantof the Onagraceae family. Native to the Northern hemisphere, fireweed has beentraditionally used by several populations to soothe skin irritation.
Defenscalp™ contains bioactive molecules such as Oenothein B, thatis known to have anti 5-alpha reductase and anti-inflammationproperties. Titrated in Oenothein B polyphenols (0.12- 0.36%), Defenscalp™normalizes sebum production (inhibitionof 5α-reductase), reinforces corneocyte cohesion ( increase in involucrumsynthesis) and modulates the scalp innate immune-inflammatory response througha normalization of Toll-like receptors(TLR2), β-Defensines (hBD2 and hBD3) andInterleurkin-8 (IL-8) expression.
This global mechanism of action gentlyinhibits the growth of Malassezia yeast to reduce dandruff production and skinirritation in order to recover a healthy scalp. Capixyl™ is an innovative and unique active complex designedto prevent and stop the hair loss process and stimulate hair growth. Capixyl™is composed of a high tech patented four amino acids biomimetic peptide with ared clover extract rich in Biochanin A.
Red Clover Extract Redclover (TrifoliumPretense) flowers have been found throughout central and Northern Europe andAsia. Biochanin A is the major isoflavone in red clover. BiochaninA is known to be an effective inhibitor of 5α-reductase type I & II activity18.
Researcheshave demonstrated that Biochanin A modulates chronic inflammation and that redclover’s isoflavones may also function as important antioxidants, limiting freeradical damage to the skin and scalp.
Acetyl Tetrapeptide-3 Biomimetic Peptide This uniquepatented peptide is a stimulator of extracellular matrix proteins favoring abetter hair anchoring. It is derived from a signal peptide which has potenttissue protective properties and stimulates tissue remodeling after the initialphase of wound healing. The peptide has a direct effect on hair follicle. Theremodeling signal will increase the size of hair follicle for better hairnumber and vitality.
Capixyl™ efficacy is based on the combined action of itstwo ingredients, allowing direction action on DHT preventing the hair cycle toshorten and hair follicle miniaturization, improving the ECM proteins in dermalpapilla surrounding hair papilla for better anchoring and promoting an increaseof follicle size. Capixyl™ also halts inflammation which is a contributing factor inhair loss.